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| Institution: |
University of Maryland, Baltimore |
| Docket: |
HR-2005-077 |
| Title: |
Anti-RGC-32 Antibody as a Marker for Colon Carcinoma |
| Summary: |
A novel antibody was produced in the investigation of the deregulation of cell cycle and overexpression of cyclins and cyclin-dependent kinases in tumor cells. Anti-RGC-32 binds to proliferating tumor cells, including tumors of colon, stomach, esophagus, prostate, lung, and brain tumors. We have identified and named RGC-32 a previously unknown protein, and cloned the gene encoding RGC-32. |
| Applications: |
There are several potential clinical applications that include the detection, imaging and possible treatment of specific types of cancer. |
| Advantages: |
Currently to our knowledge there is no commercially available antibody against RGC-32. |
| State of Development: |
Immunostaining shows RGC-32 overexpression in a range of tumor tissues. |
| R and D Required: |
N/A |
| Licensing Potential: |
UM seeks to develop and commercialize via an exclusive or non-exclusive license agreement and/or sponsored research with a company active in the area. |
| Patent Status: |
Pending U.S. Non-Provisional Patent Application |
| Related Publications: |
- Fosbrink M, Cudrici C, Tegla CA, Soloviova K, Ito T, Vlaicu S, Rus V, Niculescu F, Rus H. Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells. Exp Mol Pathol. 2009 Jan 7.
- Huang WY, Li ZG, Rus H, Wang X, Jose PA, Chen SY. Response gene to complement 32 mediates transforming growth factor beta -induced epithelial-mesenchymal transition in human renal proximal tubular cells. J Biol Chem. 2009 Jan 21.
- Vlaicu SI, Cudrici C, Ito T, Fosbrink M, Tegla CA, Rus V, Mircea PA, Rus H. Role of response gene to complement 32 in diseases. Arch Immunol Ther Exp (Warsz). 2008 Mar-Apr;56(2):115-22.
- Fosbrink M, Cudrici C, Niculescu F, Badea TC, David S, Shamsuddin A, Shin ML, Rus H. Overexpression of RGC-32 in colon cancer and other tumors. Exp Mol Pathol. 2005 Apr;78(2):116-22.
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| Files: |
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| Technology Inventors: |
Horea Rus
Matthew Fosbrink
Tudor Badea
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| Contact Info: |
Technology Licensing Officer
cvip@umaryland.edu
620 West Lexington St.
Baltimore, MD, 21201
410-706-1187 |
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